Past studies have revealed that ESCRT‐III and CD63 are necessary for effectively packaging and the secretion of LMP1 into EVs, while LMP1 can induce the secretion of EVs by Hrs, syntenin‐1, and specific ESCRT‐III subunits (such as CHMP4B, CHMP5, and CHMP6) or promote EVs secretion by upregulating syndecan‐2 (SDC2) and synaptotagmin‐like‐4 (SYTL4) through NF‐κB signaling in NPC cells.18, 19, 20. Here, NFKB1 is linked to nasopharyngeal carcinoma.