CD4 and HIV infectious disease: To assess the efficacy of antiretroviral drugs to suppress HIV infection in the MGT, male BLT mice were exposed to HIV-1JR-CSF intravenously (n = 14, peripheral blood human CD45+ cells: median 62.3%, range 44.9–74.4%; CD4+ T cells as % of CD3+ cells: median 82%, range 96.2–87.9).