As APC c.3920T>A; p.Ile1307Lys was found to be associated with a higher occurrence of CRC (including colon, rectal and sigmoid cancers, as well as polyposis; p-value = 0.0257), the unexpected frequency of the variant in low risk individuals may indicate a greater predisposition for, or prevalence of, CRC in the general Saudi population than has been previously detected. The gene discussed is APC; the disease is colorectal carcinoma.