Fifteen subjects had deletions within single exons, and seven patients had deletions spanning multiple exons in BRCA1, APC, ATM, CHEK2 or MSH2. We observed a large chromosomal rearrangement of chromosome 9 removing CDKN2A (p.14ARF) in a bone marrow cancer patient (Supplementary Tables 1 and 3), and six out of 18 unique indel events were observed in multiple members of a family. The gene discussed is APC; the disease is bone marrow cancer.