ACSL4 and cancer: Evidence to date suggests that ACSL4 functions in a variety of normal developmental and cell biological processes, including neuronal differentiation [8], germ line sex determination [9], adipocyte differentiation [10], insulin secretion [11], steroidogenesis [12, 13], and membrane fusion [14], as well as in a number of disease processes, including x-linked mental retardation [15], kidney disease [16], liver disease (NAFLD) [17], obesity [18], osteoarthritis [19], and a variety of cancers, including those of liver [20], colon [21], prostate [22, 23] and breast [22, 24, 25].