Forced expression of ACSL4 in breast cancer cells induces resistance to the cytotoxic effects of etoposide [24], cisplatin, doxorubicin and paclitaxel, possibly mediated by an increased expression of multidrug resistance transporters including ABCC4, ABCC8 and ABCG2 [71]. This evidence concerns the gene ACSL4 and breast carcinoma.