GHR and fatty liver disease: For example, Ghr disruption in the adipose tissue resulted in fat mass increase, while it was resistant to high fat induced hepatic steatosis.28 However, the hepatic Ghr disruption led to the spontaneous fatty liver under regular chow.29,30 The tissue-specific Ghr knockout mice have become useful tools to better understand the direct actions of GH in individual tissue.31 However, the effect of tissue-specific GH signaling on gut microbiota is unknown.