CXADR and Familial prostate cancer: For example, mouse-human chimeric ch6G10A antibodies against CAR (targeting the D2 membrane proximal extracellular domain) inhibited tumour growth and metastatic formation of prostate cancer and small cell lung cancer upon subcutaneous injection of DU-145 or NCI-H69 cells or orthotopic implant of highly metastatic DMS273 cells into nude mice[74].