CDH1 and neoplasm: Similarly, CAR knockdown by siRNA in HSC-2 oral squamous carcinoma cells results in reduced proliferation due to cell–cell dissociation, accompanied by cytoplasmic translocation of junctional E-cadherin in vitro, and a decrease in tumour growth in vivo in ectopic-xenograft mice models upon intraperitoneal injection of siCAR HSC-2 cells [35].