As the G‐to‐A mutation within the terminal loop of pri‐mir‐30c‐1 is associated with breast and gastric cancer (Fernandez et al, 2017) and a C‐to‐T mutation within the CNNC downstream of pri‐miR‐16 has been associated with chronic lymphocytic leukaemia (Calin et al, 2005), SRSF3‐mediated pri‐miRNA processing may play a key role in tumorigenesis (Fig 6H), suggesting that the concurrent dysregulation of SRSF3 and oncogenic miRNAs may be one of the hallmark features of cancer cells and warranting a further investigation on the role of RBPs modulating miRNA structures in cancer pathogenesis. This evidence concerns the gene SRSF3 and cancer.