In contrast, chronic PERK activation is also implicated in the pathogenesis of numerous neurodegenerative diseases involving mitochondrial dysfunction such as AD and prion disease (Moreno et al, 2012; Halliday et al, 2015, 2017b; Radford et al, 2015; Bell et al, 2016). This evidence concerns the gene EIF2AK3 and prion disease.