As vision loss primarily due to retinal degeneration is a characteristic phenotype of patients with CLN3 Batten disease (Volz et al., 2014; Staropoli et al., 2012; Kleine Holthaus et al., 2020; Zhong et al., 2020; Katz et al., 2008b; Collins et al., 2006; Kuper et al., 2021; Ku et al., 2017; Horiguchi and Miyake, 1992; Williams et al., 2006; Jarvela et al., 1997), we investigated whether CLN3Δex7/8 miniswine show retinal degeneration. Here, CLN3 is linked to retinal degeneration.