TPP1 and juvenile neuronal ceroid lipofuscinosis: In general, large animal models for Batten disease, such as the CLN1 (Eaton et al., 2019), CLN5 (Frugier et al., 2008) and CLN6 (Jolly et al., 1980; Bond et al., 2013) sheep models, as well as the CLN2 dog (Katz et al., 2008a, 2014, 2015, 2005) and CLN2 pig models (Swier et al., 2022), show more clinically relevant symptoms of the disease.