The UFA and FA genetic instruments only captured certain aspects of metabolic health (i.e. HDL‐C, SHBG, TG, AST and ALT) and did not include genetic variants related to low‐grade inflammation profile, the insulin pathway, and glycaemic control,6 which are related to metabolic health and have been proposed to increase prostate cancer risk in previous studies.23, 24. Here, INS is linked to prostate cancer.