The limitation of applying this cut-off is that patients from DM1/LADA with high GAD65-Abs titers, if combining with neurological or psychiatric disorders, might be suspicions, while this is not supported by the current study because only 2 of the 5 DM1/LADA patients with high titers GAD65 antibodies (positive for all the assays) had psychiatric disorders. This evidence concerns the gene GAD2 and psychiatric disorder.