WDFY3 and juvenile Huntington disease: For the upregulated autophagy-related genes in CE stroke patients, the heterozygous depletion of the autophagy adaptor protein WDFY3/ALFY significantly accelerates the age of onset and progression of HD (Huntington’s disease) pathogenesis, revealing the requirement of WDFY3 in clearing proteinaceous deposits (26) in the brain.