Univariate Cox regression analysis indicated that T stage (HR: 2.126, p < 0.001), M stage (HR: 4.077, p = 0.017), pathological stage (HR: 2.504, p < 0.001), tumor status (HR: 2.317, p < 0.001), and high expression of TMEM147 (HR: 2.079, p < 0.001) were independently correlated with poor outcomes in HCC patients. The gene discussed is TMEM147; the disease is hepatocellular carcinoma.