CD274 and neoplasm: In contrast, studies on ovarian tumors showed that WEE1 inhibitors promoted PD-L1 expression, recruited activated immune-related cells, and induced massive tumor cell death in a CD8+ T cell-dependent manner (Guo et al., 2022), which is attributed to the fact that WEE1 inhibitors further increase the expression of endogenous retrovirus (ERV) by downregulating FOXM1 to alleviate SETDB3/H9K3me1 inhibition.