CD274 and prostate neoplasm: In addition, downregulation of PD-L1 expression also activated the IFNAR1-JAK1 signaling pathway, promoted phosphorylation of STAT3 at Y705 and cleavage of caspases 3/7, induced the IFN-β-mediated cytotoxic pathway, and promoted apoptosis in prostate tumor cells (Tang et al., 2021).