High CHK1 expression may be associated with poor tumor prognosis, and inhibition of CHK1/2 expression by CHK1 inhibitors or other related factors (e.g., IRF-1, oxidative stress) can lead to the accumulation of DNA damage by blocking the DDR process while increasing the number of infiltrating NK cells, which promotes apoptosis of tumor cells. The gene discussed is IRF1; the disease is neoplasm.