In addition, WEE1 inhibitors significantly increased the expression of CRT, HMGB1, and other DAMPs in TME, which are closely associated with immunogenic cell death (ICD), suggesting that WEE1 inhibitors may further enhance the efficacy of immunotherapy and induce tumor cell death through ICD (Dinavahi et al., 2022). The gene discussed is CALR; the disease is neoplasm.