CFTR and cystic fibrosis: Bile duct organelles isolated from iPSCs from cystic fibrosis (CF) patients with a phenylalanine deletion at position 508 (F508del) of the CF transmembrane conductance regulator (CFTR) showed impaired chlorine transport and reduced swelling induced by CFTR-dependent forskolin, which was rescued by CFTR correcting drug VX-809 (Ogawa et al., 2015; Sampaziotis et al., 2015).