IL-8 production is closely associated with the expansion of CSCs in the TME (Kim and Kahn, 2014) and its activation has been implicated in the proliferation of CSCs in the highly aggressive triple-negative breast cancer (Hirata et al., 2022), suggesting the use of IL-8 inhibitors to sequester CSCs. This evidence concerns the gene CXCL8 and triple-negative breast carcinoma.