STAT3 and central nervous system cancer: The following molecules are known to inhibit JAK-STAT signaling: 1) Mir-218 inhibits the JAK-STAT3 pathway resulting in downregulation of lung CSC’s self-renewal capacity (Yang et al., 2017); 2) Ajuba, a LIM domain-containing scaffolding protein, promotes the proliferation of colorectal CSCs through suppression of JAK1/STAT1 (Jia et al., 2017); 3) Von Hippel–Lindau (VHL) cell surface proteins act via the JAK2/STAT3 pathway to suppresses self-renewal ability of glioma CSCs (Yang et al., 2020).