SPOP and gastric cancer: Speckle-type POZ (SPOP) is a unique protein in that it at times inhibits Hh signaling in gastric cancer through increasing the degradation of Gli2 (Zeng et al., 2014), while SPOP can also upregulate Hh signaling, decreasing CRC CSC’s rate of apoptosis (Zhi et al., 2016).