JAK-STAT signaling behaves as a double-edged sword, whereby STAT3 is commonly linked to CSC’s immunosuppression capacity and aberrant TME, while STAT 1/2 activates an anti-tumor immune response via interferons, (i.e., IFN I/II) (Owen et al., 2019; Yang et al., 2020). This evidence concerns the gene SOAT1 and neoplasm.