The following molecules are known to inhibit Notch signaling: 1) microRNA-34a is a potent tumor suppressor known to inhibit gastric CSCs (Jang et al., 2016), 2) PER3 polymorphisms are associated with colorectal CSCs, 3) miR-200b-3p expression is associated with pancreatic CSCs and downregulates colorectal cancer (CRC) cells (Feifei et al., 2019), and 4) miR-26a expression is found on osteosarcoma CSCs and inhibits ovarian (Gao et al., 2020) and colorectal cancers (Yang et al., 2020; Chen et al., 2021b). Here, PER3 is linked to colorectal cancer.