XPO1 and cancer: Missense mutations were identified in 3 cancer gene drivers: ATR (p.(His4Tyr)) and Rad3-related protein, implicated in replication stress response (37); USP7 (p.(Arg634Asp)) for ubiquitin specific protease 7, member of the deubiquitinating enzyme family (38); and XPO1 (p.(Ser1031Thr)) a nuclear export protein implicated in cellular homeostasis (Supplementary Table 5) (39).