PCU-018 had a diploid profile with an important number of deletions (383 deleted cancer genes) spread widely all over the genome with homozygous deletions of the tumor suppressor TSC1 and MACROD2, a hydrolase, which removes mono-ADP-ribosylation and which is implicated in chromosome instability in colorectal cancer (36). This evidence concerns the gene MACROD2 and colorectal cancer.