We conclude that apoptosis of mesothelioma cells in response to CIT treatment is mediated by activation of pro-apoptotic signaling (JNK, HSP60) and – depending on the cellular background – inhibition of AKT/ERK, thus overriding pro-survival signaling by c-Jun, CREB and FAK (Figure 6). The gene discussed is CREB1; the disease is mesothelioma.