On analyzing the relationship between TXNL4A and the pathological HCC features, TXNL4A expression was found to be correlated with T-stage (p < 0.001), pathologic stage (p < 0.001), serum AFP level (p = 0.006), vascular invasion (p = 0.022), and mortality events. The gene discussed is TXNL4A; the disease is hepatocellular carcinoma.