Firstly, TRPC6 is a non-selective calcium channel known to be involved in heart failure in general and in cardiac remodeling in animal models (19), and in our previous studies, TRPC6 knockout (21) and pharmacological inhibition of TRPC6 in vitro and in wild-type mice (20) attenuated doxorubicin-induced cardiotoxicity, respectively. This evidence concerns the gene TRPC6 and heart failure.