TRPC6 and heart failure: Therefore, taken together, our data and other published studies suggest that (1) higher expression levels of TRPC6 are associated with cardiac remodeling and heart failure; (2) genetic variants at TRPC6 are associated with TRPC6 expression levels; and (3) inhibition of TRPC6 may be a useful cardioprotective therapy for doxorubicin-induced heart failure.