DS-8201, an ADC, is composed of trastuzumab, a cleavable peptide linker, and a topoisomerase I inhibitor (DXd) (45).Unlike T-DM1, which has a drug-to-antibody ratio (DAR) of 3.5, DS-8201 boasts a DAR of 8, thereby enhancing its potency even against tumor cells exhibiting low HER2 expression. Here, ERBB2 is linked to neoplasm.