The activity of HDAC6 has been linked with PD pathogenesis (Lemos and Stefanova, 2020) and HDAC6 is highly expressed in LB in PD patients’ brain sections, indicating that HDAC6 may play a key role in the clearance of those misfolded and aggregated protein (Kawaguchi et al., 2003; Du et al., 2010; Richter-Landsberg and Leyk, 2013). The gene discussed is HDAC6; the disease is Parkinson disease.