PTENP1 and osteoporosis: In addition, Wang et al. found that the pseudogene PTENP1 regulates miR-214 expression by inhibiting PI3K/AKT/NF-κB signaling pathway to suppress osteoclast differentiation and reduce osteoporosis in an ovariectomy-induced osteoporosis mouse model (Wang C. G. et al., 2020).