It should be noted that brain injury in autism may have distinct consequences than in the published studies of human subjects and experiments in APP-transgenic mice, as in autism the APP processing is skewed toward α- and γ-secretase cleavage (Sokol et al., 2006; Bailey et al., 2008; Ray et al., 2011), thus, production of Aβ11–40 and Aβ11–42 is expected to be favored over the full-length species. Here, APP is linked to autism.