NF-κB overexpression is related to COPD, and it regulates the release of inflammatory mediators such as interleukin 1 beta (IL1β), C-X-C motif chemokine ligand 8 (CXCL8) and cytochrome c oxidase subunit II (COX2) in COPD (Zhou et al., 2018). This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.