KEAP1-independent regulation of NRF2 includes epidermal growth factor receptor (EGFR)/rat sarcoma virus (RAS)/rapidly accelerated fibrosarcoma (RAF)/extracellular signal-regulated kinase 1/2 (ERK) signaling which activates NRF2 (Huo et al., 2014) and are also the driver genes of LUAD (Krall et al., 2017). The gene discussed is KEAP1; the disease is fibrosarcoma.