Selective deletion of the X-linked methyl-CpG-binding protein 2 (Mecp2) gene, a key genetic cause of Rett Syndrome, in peripheral somatosensory neurons results in aberrant tactile sensitivity by disrupting GABAergic presynaptic inhibition to the CNS (Orefice et al., 2016). Here, MECP2 is linked to atypical Rett syndrome.