Regarding the involvement of the EGFR signaling pathway in the induction and progression of cervical cancer and the ability of E5 to increase the EGFR recycling process within the HPV-infected cells, it is recommended that the E5 protein could exacerbate the severity of cervical cancer via elevating the activity of EGFR signaling pathway [25]. The gene discussed is EGFR; the disease is cervical cancer.