ARHGEF15 and cervical carcinoma: To complete these previously published results, in this experimental study, we used siRNA with the ability to silence HPV-16 E5 oncogene (E5-siRNA) to find the effect of E5 suppression on the several aspects of the cellular process which are essential in the maintenance of cancerous status in cervical cancer cells such as the apoptosis, cell cycle, and their related genes.