Thus, cGAS is critical in immune surveillance or tumor restraint [8,9]; Apart from acting as an anti-inflammatory and autoimmune regulator, cGAS also modulates autophagy [10] and senescence [11]; it also inhibits homologous recombination repair (HRR) of DSBs in a STING-independent manner [12,13]. This evidence concerns the gene STING1 and neoplasm.