It has been reported that nuclear enrichment of cGAS induced by IR and DNA damage agents inhibits HRR [15], allowing further accumulation of DNA damage in cancer and establishing a feed-forward loop of chromosomal instability [40], IR-induced nuclear displacement of exogenous and endogenous cGAS was also observed in the GC cells, which highlights an exciting role of nuclear cGAS in promoting tumors sensitivity to the DNA damaging agents. This evidence concerns the gene CGAS and cancer.