However, CRCC is a highly vascular tumor, and in the last 20 years, tyrosine kinase inhibitors (TKI) and anti-angiogenic agents targeting the VEGF pathway have been found to benefit patients with CCRCC, including targeted rapamycin inhibitors (MTOR) as well [5–7]. This evidence concerns the gene VEGFA and nonpapillary renal cell carcinoma.