Among them, based on several clinical trials [65,67,70], alpha-PD-1/PD-L1 in combination with angiogenesis inhibitors (including pembrolizumab in combination with axitinib, nivolumab in combination with cabozantinib and avelumab in combination with axitinib) were approved as first-line treatment for renal cell carcinoma. This evidence concerns the gene CD274 and hereditary clear cell renal cell carcinoma.