Prior to ICD induction and cell membrane disruption, through endoplasmic reticulum stress, CRT translocates and is exposed to the cell membrane where it acts as a “eat me” signal for phagocytosis [93], and CRT on the cell membrane surface (ecto-CRT) enhances the immunogenic recognition and phagocytosis of dead cancer cells by APCs (Fig. 2). This evidence concerns the gene CALR and cancer.