Surprisingly, in the present study, results obtained using an in vitro small-molecule compound screening system, showed that an old alcohol-abuse drug DSF significantly reduced the expression of the anti-apoptosis marker B-cell lymphoma/leu kemia-2 (Bcl-2) while increasing the expression of the apoptosis markers Bcl2 associated X (Bax) and cleaved caspase-3; these results indicated that DSF promotes human epithelial ovarian cancer cells apoptosis. This evidence concerns the gene BCL2 and ovarian carcinoma.