In 2016, Aggarwal et al. found a larger proportion of patients with TPS <1% in the subgroup with non-squamous cell carcinoma compared with squamous cell carcinoma (26% vs. 19%); that is, in LUADs, patients’ PD-L1 is more likely to be negative compared with LUSCs [26], which is similar to our findings. The gene discussed is CD274; the disease is squamous cell carcinoma.