By analyzing the correlation between the expression level of PD-L1 and clinicopathological parameters in 1,008 LUSCs or LUADs, we conclude that the expression of PD-L1 seems to be higher in males, smokers, squamous cell carcinoma tumors with a maximum diameter >3 cm, patients with poor differentiation and/or high TNM stage. The gene discussed is CD274; the disease is squamous cell carcinoma.