It is possible that the reduced level of NcoA2 as a result of hypoxia suppresses the transactivation of the xenobiotic-sensitive element (XRE) of AhR, as demonstrated, for example, in HEK293T cells [24], and it is the nuclear receptor coactivator (NcoA2) that is the key trigger of molecular cascades in meningiomas subjected to ischemic hypoxia. The gene discussed is AHR; the disease is meningioma.