Abbreviations: GSK3, Glycogen synthase kinase 3; PTEN, Phosphatase and tensin homolog; PTPRO, protein tyrosine phosphatase receptor type O; PPAR, Peroxisome proliferator-activated receptor; ACOX1, acyl-coenzyme A oxidase 1; AMPK, AMP-activated protein kinase; CAF, cancer-associated fibroblast; DCs, dendritic cells; TAMs, tumor associated macrophages; FFAR2, Free fatty acid receptor 2. The gene discussed is PTPRO; the disease is cancer.