As a matter of fact, a high percentage of positive immunohistochemical staining of SPINK1 was observed in colorectal cancer patients [27,28], and interestingly, Chang Hyeok Ahnalso noticed that the increased expression of Beclin-1 was detected in 95% of the tumor tissues of the CRC patients [29]. The gene discussed is SPINK1; the disease is colorectal cancer.