As a matter of fact, a high percentage of positive immunohistochemical staining of SPINK1 was observed in colorectal cancer patients [27,28], and interestingly, Chang Hyeok Ahnalso noticed that the increased expression of Beclin-1 was detected in 95% of the tumor tissues of the CRC patients [29]. This evidence concerns the gene BECN1 and colorectal carcinoma.