Likewise, Gorzalczany et al. stated that EGFR activation suppressed autophagic event and EGFR inhibitor enhanced autophagy in non-small-cell lung carcinoma (NSCLC) [25], which were contrary to our ‘enhanced autophagy’ occurred in SPINK1-OE HT29 cells. Here, SPINK1 is linked to non-small cell lung carcinoma.