SPINK1 and colorectal carcinoma: In this investigation, we presented some new data with respect to the molecular pathway through which SPINK1 may simulate HT29 cell’s growth, and these new findings partially filled the gaps among SPINK1, autophagy and tumor cell’s survival, and will possibly even shed light on the discovery of the signaling route that is responsible for the proliferation, invasion and metastasis of CRC.