Benzoxazoles are privileged building blocks for the synthesisofbiologically active ligands targeting a plethora of crucial targets/pathwaysdue to their unique features allowing them to effectively bind todiverse biological targets with distinct affinities.27−31 Several studies have revealed that benzoxazoles exert marked cytotoxicactivity against a variety of cancer cell lines through diverse mechanismsincluding induction of apoptosis, inhibition of Akt phosphorylation,and so on.32−39. The gene discussed is AKT1; the disease is cancer.