AKT1 and cancer: Akt belongs to thefamily of serine/threonine-specific proteinkinases essential for regulating crucial cellular processes includingcell survival, proliferation, growth, apoptosis, and glucose metabolism.The abnormal overexpression or activation of Akt is involved in avariety of human malignancies and therefore inhibiting Akt has emergedas a pivotal strategy for the treatment of various types of cancer,particularly B-cell malignancies, NSCLC, and breast cancer.11−13 Despite the large number of Akt inhibitors developed to date, theU.S.