Ngo et al. (2022), found that IGF-1R contributes to the insistent malignant features and poor prognosis of HCC, in addition to chemotherapy resistance that could be reversed by downregulation of its gene expression through binding of microRNA-944 to 3′ prime end of IGF-1R to inhibit the gene translation [21]. This evidence concerns the gene IGF1R and hepatocellular carcinoma.