IGF1R and hepatocellular carcinoma: For example, circLARP4 is highly expressed in HCC tissues leading to inhibition of p53 and p21 actions resulting from miR-761 sponging [28], He et al. (2020) approved that the increased concentrations of circ_0000517 in HCC tissues caused increased levels of IGF-1R due to sponging of miR-326 and enhancing the hepatocarcinogenesis [29].