The ROC curve analysis was used to analyze the diagnostic accuracy of the investigated plasma circSERPINA3, miR-944, GPC3, and AFP for HCV-induced HCC group, the AUC values (Table 4) were analyzed to calculate the sensitivity and specificity (Table 4) (See Fig. 6a, 6b, c, d) respectively. The gene discussed is GPC3; the disease is hepatocellular carcinoma.