In addition, the positive correlation between the gene expression level of circSERPINA3 and the E-cadherin protein level in both the HCV (r = 0.9652) (see Fig. 3d) and HCV-induced HCC (r = 0.9756) (see Fig. 3e) groups indicated that HCV-infected patients are at high risk of developing HCC and the HCC patients had poor prognoses with more chances for metastasis. The gene discussed is CDH1; the disease is hepatocellular carcinoma.