IGF1R and hepatocellular carcinoma: According to Lv et al. (2019), upregulation of miR- 944 gene expression level has a malignancy suppression effect on HCC cells through suppression of tumor cell proliferation besides, augmentation of apoptosis by targeting the oncogenic tyrosine kinase receptor IGF-1R and deactivation of PI3K/Akt signaling mechanisms [16].