(2) Assessment of the cytotoxic response against the tumor cells through the significant decrease of FOXP3, CD25, CD4 regulatory T cells, in addition to the significant increase in the expression of CD8 (CTL), CD4 (Th), and CD103 memory cells, which mediated killing of the BCCs through increased production of IFN-γ and LDH. The gene discussed is IFNG; the disease is neoplasm.