CEP55 and renal cell carcinoma: To further investigate whether CEP55 was involved in M2-EVs-miR-342-3p dependent regulation in the tumorigenesis and development of RCC, potential downstream target genes for miR-342-3p were obtained on ENCORI and were then intersected with the differentially down-regulated genes in GSE36895 dataset and the E3 ubiquitin ligase of CEP55 predicted by the UbiBrowser database (Figs. 4B–4C).