In conjunction with existing evidence, we preliminarily indicated that M2-EVs encapsulated miR-342-3p could promote the CEP55 expression by targeting NEDD4L and inhibiting NEDD4L expression, thus consequently promoting the proliferative, migratory and invading properties of RCC cells via activation of the PI3K/AKT/mTOR pathway. Here, NEDD4L is linked to renal cell carcinoma.