Patients with severe Omicron pneumonia had a significantly higher age (p < 0.001), higher blood urea nitrogen (p = 0.049), higher CRP (p = 0.006), lower hematocrit (p = 0.014), lower partial pressure of arterial oxygen (p < 0.001), lower oxygen saturation (p < 0.001), higher CT consolidation volume (p = 0.003), higher consolidation percentage (p < 0.001), higher infiltration percentage (p = 0.031), higher total lesion volume (p = 0.001), higher total lesion percentage (p < 0.001), and more cases with pleural effusion (p < 0.001). This evidence concerns the gene CRP and Pleural effusion.