Myocilin (MYOC), optineurin (OPTN), WD repeat domain 36, (WDR36), cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), glutathione S-transferase mu 1 (GSTM1), and Neurotrophin (NTF4) have been widely linked to POAG (37, 38). The gene discussed is OPTN; the disease is open-angle glaucoma.