A wide variety of molecular signals promote RGC and optic fibers death in glaucoma OND, among them it has to be considered: OS, INF, mitochondrial failure, excitotoxicity, neurotrophin deprivation, axonal transport dysfunction, apoptosis, neuroglia alterations, synaptic loss, etc. (31, 35) Trying to understand the involvement of neurotrophins in POAG could help improve knowledge for better eye and vision care in glaucoma. Here, BDNF is linked to glaucoma.