IL6 and chronic obstructive pulmonary disease: When combined with TLR2/4 or non‐TLR PRRs dectin‐1 on the surface of pulmonary macrophages, Aspergillus upregulates the expression of high mobility group box 1, which stimulates macrophages to release TNF‐α, IL‐1β, IL‐6, IL‐33, and other inflammatory factors, leading to the exacerbation of COPD.135