NOX4 and diabetes mellitus: The molecular implications of the observed effects require further investigation into these topics, and the next steps in the study may include identifying the interactions between genes involved in lipid metabolism (SREBP1c and FASN), inflammation (F4/80 receptor, IFNγ, and TNFα), fibrosis (TGFβ andαSMA), and oxidative stress (NOX1 and NOX4) and IDO1-KYN-AHR axis in diabetic liver treated with NLE.