Firstly, considering that the topic of this study is the effects of DHT mediated by ZIP9 on hippocampal synaptic plasticity and learning and memory, we did not detect hippocampal Aβ in APP/PS1 mice, although senile plaque formed by excessive deposition of Aβ is one of the pathological features of AD. Here, SLC39A9 is linked to Alzheimer disease.