ACSL1 and Familial prostate cancer: In the triglyceride synthesis pathway, Long Chain Acyl-CoA Synthetases (ACSL) 1 promote prostate cancer progression by increasing fat production and fatty acids β-oxidation, knockout of ACSL1 inhibits the proliferation and migration of prostate cancer cells in vitro, as well as the growth of prostate xenografts in vivo (16).