Moreover, Parathyroid hormone related proteins derived from tumor cells can inhibit fat formation by downregulating the expression of PPARγ (83), and induce adipose tissue browning by upregulating the expression of heat producing genes such as coupling protein 1 (UCP1), inducing fat breakdown to obtain more energy from mature adipocytes, and promoting bone metastasis. The gene discussed is UCP1; the disease is neoplasm.