ST8SIA1 and melanoma: For example, increased expression of GD3 synthase and/or GD2 synthase mRNA is frequently observed in cancer; the promoter region of ST8SIA1 gene has been found to be relatively overexpressed in glioblastoma, melanoma and breast cancer cell lines; GD2-positive tumors highly express OAcGD2, such as sarcoma, neuroblastoma, glioma, breast cancer and small cell lung cancer cells; A large proportion of small cell lung cancer expressed very high levels of Fuc-GM1; High levels of OAcGD3 are shown in melanoma (70).