Importantly, cholesterol metabolism can affect multiple carcinogenic pathways, including PI3K/AKT/mTOR, NF-κB,WNT/β-catenin, Hedgehog, TP53/SREBP, NPC1/mTOR, RTK/Ras, and other signal pathways related to regulating tumor cell proliferation, growth, and angiogenesis. This evidence concerns the gene AKT1 and neoplasm.