In breast cancer, LXR-α Cancer cell lines with high mRNA expression are more sensitive to the inhibition of 22 (R)-HC induced (11), and estrogen receptor status is negatively correlated with the ability of LXR to induce typical target gene expression, that is, LXR in breast cancer cells with negative estrogen receptor has a stronger ability to induce typical target gene expression (12). The gene discussed is ESR1; the disease is breast carcinoma.