Additionally, NF-κB signal enhances the activation of WNT/β-catenin in intestinal epithelial cells through CES1 dependent lipid catabolism, induces non stem cell dedifferentiation that obtains tumor initiation ability, stimulates tumor inflammation and survival of intestinal tumor cells (51), and participates in the regulation of energy metabolism, metabolic stress adaptation, and epithelial mesenchymal transition. This evidence concerns the gene CES1 and neoplasm.