PPARA and prion disease: The Gene Set Enrichment Study (GSEA) analysis of these 327 genes indicated that the up-regulated FRGs in NASH were involved in carboxylic acid binding, catalytic activity, the small molecule metabolic process, the PPAR signaling pathway, and metabolic pathways, while the down-regulated FRGs were engaged in animal organ development, regulation of cell population proliferation, anatomical structure formation involved in morphogenesis, human T-cell leukemia virus 1 infection, the AGE-RAGE signaling pathway in diabetic complications, and prion disease (Figures 3B, C).