VEGFA and osteogenesis imperfecta: In our previous study, the downregulation of DKK1 in MBTPS2-OI cells - similarly to the overexpression of ADAMTS12 and VEGFA - was interpreted as a mechanism in MBTPS2-OI cells to counteract the inhibitory effect of DKK1 on osteoblast differentiation and bone formation, and its promotion of osteoclastogenesis (27) and adipogenesis, thus as an attempt to rescue bone formation.