In our previous study, the downregulation of DKK1 in MBTPS2-OI cells - similarly to the overexpression of ADAMTS12 and VEGFA - was interpreted as a mechanism in MBTPS2-OI cells to counteract the inhibitory effect of DKK1 on osteoblast differentiation and bone formation, and its promotion of osteoclastogenesis (27) and adipogenesis, thus as an attempt to rescue bone formation. The gene discussed is DKK1; the disease is osteogenesis imperfecta.