Among the population that may benefit of TOP5668 and TOP5300 treatments there are PCOS patients: in the same study, it has been demonstrated that granulosa cells, collected from women affected by PCOS, and treated with TOP5300 produce an increased amount of estradiol compared to the cells treated with the recombinant FSH, commonly used in clinic (42). The gene discussed is BRD2; the disease is polycystic ovary syndrome.