Taking whether DKD occurs or not as the dependent variable (assignment: DKD (-) =1, DKD (+) =2), the multivariate logistic regression analysis was performed and the results showed: after adjusting for SBP, DSP, eGFR, BUN, SUA, RBP, TC and other factors, we found the increased Cat-S and CysC were risk factors for the onset of DKD (P < 0.05). The gene discussed is PIMREG; the disease is diabetic kidney disease.