PIMREG and type 2 diabetes mellitus: Taking whether DKD occurs or not as the dependent variable (assignment: T2DM=1, early DKD=2, clinical DKD=3), the results showed that after correcting SBP, DBP, SUA, TC, eGFR, BUN, RBP and other factors, we found that Cat-S and CysC were independent risk factors for DKD and clinical DKD in T2DM patients (P<0.05).