In the nucleus, β-catenin binding to TCF/LEF conducts the separation of co-receptors, including Groucho/TLE; as a result, it interacts with co-activators such as cell cycle-related and expression elevated protein in tumor (CREPT), four-and-a-half-LIM-domain 2 (FHL2), and CREB-binding protein (CBP/p300) and remodelers of chromatin such as brahma-related gene 1 (Brg-1) [21,23–29]. This evidence concerns the gene FHL2 and neoplasm.