CD274 and neoplasm: In this regard, in phase II clinical trial in patients with cervical cancer and resistant to treatment, it was observed that following the combination therapy of pembrolizumab as an anti-PD-L1 drug along with vitamin D (as a concomitant drug) and curcumin (drug complement), the anti-tumor immune response is strengthened (trial number: NCT03192059) [171,213].