On the other hand, elevating the activity of the Wnt signaling pathway causes the expression of essential genes, including c-MYC (a regulator gene and proto-oncogene), Nanog (a transcription factor sustaining pluripotency of embryonic stem cells), Oct4 (octamer-binding transcription factor 4), Sox2 (sex-determining region Y-box 2), Snai1 (a zinc finger protein regulating epithelial to mesenchymal transition), and Twist (a primary helix-loop-helix transcription factor), to be increased, resulting in tumor development [115]. The gene discussed is SOX2; the disease is neoplasm.